{"product_id":"recombinant-glucocorticoid-receptor-monoclonal-antibody-e-ab-81561","title":"Recombinant Glucocorticoid Receptor Monoclonal Antibody - E-AB-81561","description":"Recombinant Glucocorticoid Receptor Monoclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: E-AB-81561-50, E-AB-81561-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: Glucocorticoid Receptor\n\nTarget Synonym: GR; GCR; GRL; GCCR; GCRST\n\nConjugation: Unconjugated\n\nHost: Rabbit\n\nSpecies Reactivity: Human, Mouse, Rat\n\nApplication: WB, IF\n\nIsotype: IgG\n\nClonality: Rabbit Monoclonal\n\nClone No.: R04-8C8\n\nUNIProt ID: P06537\n\nBackground: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:10678832). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay . Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (PubMed:15037546).\n\nConcentration: 300 μg\/mL\n\nImmunogen: Recombinant protein of mouse Glucocorticoid Receptor\n\nBuffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein\n\nPurification Method: Affinity Purified\n\nDilution: WB 1:500-1:1000 IF 1:50-1:100\n\nCalculated MW: 86kDa\n\nObserved MW: 94\/91kDa\n\nStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\n\nShipping: Ice bag\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"50μL","offer_id":43149044580531,"sku":"E-AB-81561-50","price":224.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":43149044613299,"sku":"E-AB-81561-100","price":364.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_2c435305-357e-4db2-92e2-88d832f5341d.png?v=1710339143","url":"https:\/\/afsbio.com\/products\/recombinant-glucocorticoid-receptor-monoclonal-antibody-e-ab-81561","provider":"AFSBio Inc.","version":"1.0","type":"link"}