{"product_id":"recombinant-gmf-β-human-bk0068","title":"Recombinant GMF-β, Human - BK0068","description":"\u003cp\u003eRecombinant GMF-β, Human\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BK0068-10, BK0068-50\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eSource: Escherichia coli\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: 16.7 kDa, observed by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95% by SDS-PAGE and HPLC analyses.\u003c\/p\u003e\n\n\u003cp\u003eBiological Activity: Bioassay data are not available.\u003c\/p\u003e\n\n\u003cp\u003ePhysical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized after extensive dialysis against PBS.\u003c\/p\u003e\n\n\u003cp\u003eAA Sequence: MSESLVVCD VAEDLVEKLR KFRFRKETNN AAIIMKIDKD KRLVVLDEEL EGISPDELKD ELPERQPRFI VYSYKYQHDD GRVSYPLCFI FSSPVGCKPE QQMMYAGSKN KLVQTAELTK VFEIRNTEDL TEEWLREKLG FFH\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.2 EU\/μg, determined by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Reconstituted in ddH2O at 100 μg\/mL.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Lyophilized recombinant human Glia Maturation Factor beta (rhGMF-beta) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhGMF-beta remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.\u003c\/p\u003e\n\n\u003cp\u003eUsage: This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Glia Maturation Factor beta (GMF-beta) is a 17 kDa brain specific protein that belongs to the ADF\/cofilin superfamily. It is a neurotrophin that induces maturation of neurons and glial cells. Unlike other neurotrophins, GMF-β lacks a leader sequence and can be phosphorylated by protein kinase A and protein kinase C suggesting its role in signal transduction. GMF-β is a prominent mediator of inflammation in the central nervous system and can activate several inflammation-related genes such as tumor necrosis factor-α and interleukin-1β. Researchers have shown there are significantly higher levels of GMF-β protein in all the effected regions of Alzheimer’s disease (AD) brains suggesting an important role of GMF-β in AD pathogenesisRecombinant human Glia Maturation Factor beta (rhGMF-beta) produced in E.coli is a single non-glycosylated polypeptide chain containing 142 amino acids. rhGMF-beta has a molecular mass of 16.7kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"10μg","offer_id":42882240118963,"sku":"BK0068-10","price":256.94,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":42882240151731,"sku":"BK0068-50","price":813.32,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_e67a9373-c6f5-42ad-a12c-f2a5a11d6007.jpg?v=1702049848","url":"https:\/\/afsbio.com\/products\/recombinant-gmf-%ce%b2-human-bk0068","provider":"AFSBio Inc.","version":"1.0","type":"link"}