{"product_id":"recombinant-human-β-defensin-1-defb1-protein-pksh033264","title":"Recombinant Human β-Defensin 1\/DEFB1 Protein - PKSH033264","description":"\u003cp\u003eRecombinant Human β-Defensin 1\/DEFB1 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033264-10, PKSH033264-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: β-Defensin 1; DEFB1\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Beta-Defensin 1; BD-1; hBD-1; Defensin Beta 1; DEFB1; BD1; HBD1\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Microbiology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: None\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P60022\u003c\/p\u003e\n\n\u003cp\u003eAccession: P60022\u003c\/p\u003e\n\n\u003cp\u003eBackground: β-Defensin 1 (DEFB1) is a member of the β-defensin family, which is highly expressed by epithelial cells. β-defensins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal peptide. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-defensin 1 is an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. Defects in β-Defensin-1 contribute to asthma diagnosis, with apparent gender-specific effects in human. β-defensin 1 may also play a role in the pathogenesis of severe sepsis. In addition, β-defensin 1 is associated with induction profiles in gingival keratinocytes.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Gly22-Lys68\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 130mM NaCl, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 5.1 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 6 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43113939370163,"sku":"PKSH033264-10","price":180.6,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43113939402931,"sku":"PKSH033264-50","price":525.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_c97b822b-9cc9-49d7-8e43-d63b753d9c99.png?v=1709548956","url":"https:\/\/afsbio.com\/products\/recombinant-human-%ce%b2-defensin-1-defb1-protein-pksh033264","provider":"AFSBio Inc.","version":"1.0","type":"link"}