{"product_id":"recombinant-human-β-defensin-4a-defb4a-protein-pksh033266","title":"Recombinant Human β-Defensin 4A\/DEFB4A Protein - PKSH033266","description":"\u003cp\u003eRecombinant Human β-Defensin 4A\/DEFB4A Protein\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSH033266-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: β-Defensin 4A; DEFB4A\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Beta-Defensin 4A; Beta-Defensin 2; BD-2; hBD-2; Defensin; Beta 2; Skin-Antimicrobial Peptide 1; SAP1; DEFB4A; DEFB102; DEFB2; DEFB4; DEFB4B\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Microbiology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: None\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: O15263\u003c\/p\u003e\n\n\u003cp\u003eAccession: O15263\u003c\/p\u003e\n\n\u003cp\u003eBackground: β-Defensin 4A is a membrane-active cationic peptide that functions in inflammation and innate immune responses. There are at least 30 β-Defensins, which are distinguished from α-Defensins by the connectivity pattern of their three intermolecular disulfide bonds. Members of the Defensin family are highly similar in protein sequence. This gene encodes Defensin, DEFB4; , which has broad-spectrum antimicrobial activity and may play an important role in innate epithelial defense. They are highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. β-Defensin 4A has low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. The 45 amino acid mature human BD3 shares 38% and 33% amino acid sequence identity with mouse and rat BD3, respectively.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Gly24-Pro64\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 130mM NaCl, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 4.3 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 9 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104248823987,"sku":"PKSH033266-50","price":366.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_479b4842-2f5a-4b71-953f-525396018f87.png?v=1709292872","url":"https:\/\/afsbio.com\/products\/recombinant-human-%ce%b2-defensin-4a-defb4a-protein-pksh033266","provider":"AFSBio Inc.","version":"1.0","type":"link"}