{"product_id":"recombinant-human-2b4-cd244-protein-fc-tagactive-pksh031921","title":"Recombinant Human 2B4\/CD244 Protein (Fc Tag)(Active) - PKSH031921","description":"Recombinant Human 2B4\/CD244 Protein (Fc Tag)(Active)\n\nSize: 100μg\n\nCatalogue Number: PKSH031921-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: 2B4; CD244\n\nTarget Symptom: Natural killer cell receptor 2B4; NK cell activation-inducing ligand; NAIL; NKR2B4; h2B4; SLAM family member 4; SLAMF4; CD244; 2B4\n\nResearch Area: immunology; Stem cells\n\nTarget Species: Human\n\nExpression Host: HEK293 Cells\n\nApplication: ELISA\n\nFusion Tag: C-hFc\n\nAccession: NP_057466.1\n\nBackground: The CD244 antigen; also known as 2B4; is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating NK cell cytotoxicity and cytokine production; which is expressed on all NK cells; a subpopulation of T cells; monocytes and basophils. The 2B4 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor; human 2B4 can effectively activate and enhance NK cell– mediated cytotoxicity; induce secretion of IFN-γ and matrix metalloproteinases (MMPs); as well as NK cell invasiveness. As a cell surface glycoprotein of the Ig-superfamily structurally related to CD2-like molecules such as CD2; CD48; CD58; CD84; Ly-9; and SLAM; 2B4 (CD244) is expressed on all human NK cells; a subpopulation of T cells; basophils and monocytes. 2B4 activates NK cell mediated cytotoxicity; induces secretion of IFN-gamma and matrix metalloproteinases; and NK cell invasiveness. Detection: Antibodies Detection: ELISA Antibodies Detection: IP Antibodies Detection: FCM Antibodies Co-inhibitory Targets\n\nActivity: Immobilized human CD48 at 10 μg\/ml (100 μl\/well) can bind recombinant human 2B4 \/ CD244 with a linear range of 0.004-0.4 μg\/ml.\n\nSequence: Met 1-Arg221\n\nPurity: \u0026gt; 97 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 49 kDa\n\nObserved MW: 70-80 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104330580147,"sku":"PKSH031921-100","price":1024.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_b4010dc3-4667-4535-8e98-9d6db7d65ea2.png?v=1709294483","url":"https:\/\/afsbio.com\/products\/recombinant-human-2b4-cd244-protein-fc-tagactive-pksh031921","provider":"AFSBio Inc.","version":"1.0","type":"link"}