{"product_id":"recombinant-human-4-1bbl-tnfsf9-protein-his-tagactive-pksh032023","title":"Recombinant Human 4-1BBL\/TNFSF9 Protein (His Tag)(Active) - PKSH032023","description":"\u003cp\u003eRecombinant Human 4-1BBL\/TNFSF9 Protein (His Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032023-20, PKSH032023-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: 4-1BBL; TNFSF9\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL; TNFSF9\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Cancer; immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P41273\u003c\/p\u003e\n\n\u003cp\u003eAccession: P41273\u003c\/p\u003e\n\n\u003cp\u003eBackground: Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1BBL is a 254 amino acids cytokine that is expressed in brain; placenta; lung; skeletal muscle and kidney. TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine may have a role in activation-induced cell death (AICD) and cognate interactions between T-cells and B-cells\/macrophages. It has also been shown to be required for the optimal CD8 responses in CD8 T cells; and is thought to be involved in T cell-tumor cell interaction.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized Human 4-1BB-His(Cat: PKSH032025) at 10μg\/ml(100 μl\/well) can bind Biotinylated Human 4-1BBL-His. The ED50 of Human 4-1BBL-His is 147.3 ug\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Arg71-Glu254\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB; 150mM NaCl; pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 41.8 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 16-20 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43118133969075,"sku":"PKSH032023-20","price":348.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43118134001843,"sku":"PKSH032023-100","price":1034.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_8cea806e-61d4-44e3-986b-12e50c3f3966.png?v=1709636823","url":"https:\/\/afsbio.com\/products\/recombinant-human-4-1bbl-tnfsf9-protein-his-tagactive-pksh032023","provider":"AFSBio Inc.","version":"1.0","type":"link"}