{"product_id":"recombinant-human-abcg2-protein-his-tag-pdeh100426","title":"Recombinant Human ABCG2 protein (His tag) - PDEH100426","description":"\u003cp\u003eRecombinant Human ABCG2 protein (His tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDEH100426-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ABCG2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: \u003cbr\u003e\nBroad substrate specificity ATP-binding cassette transporter ABCG2; ABCG2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9UNQ0\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer; Metabolism; \u003cbr\u003e\nNeuroscience; Signal Transduction; Stem Cells;\u003c\/p\u003e \n\n\u003cp\u003eBiochemicals\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9UNQ0\u003c\/p\u003e\n\n\u003cp\u003eBackground: Hematopoietic stem cells are known to express a membrane transporter molecule, known as P-glycoprotein (Pgp), that is encoded by the multidrug resistance gene 1 (MDR1). Expression of Pgp appears to confer a proliferative advantage to stem cells through its anti-apoptotic effects. An additional transporter molecule known as ABCG2 (ATP-binding cassette gene 2) or Bcrp1 (Breast cancer resistance protein 1), first identified in a breast cancer cell line, is expressed on stem cells. ABCG2 belongs to a family of molecules that span the cell membrane six times and can exist as either homo or hetero dimers linked by a short intracellular flexible linker region that plays an important role in the efflux of a wide range of substrates\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Gly 300\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 32.89 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 32 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43083561140403,"sku":"PDEH100426-100","price":165.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_1b9169b6-0739-4ce8-8b5c-f68e691650e0.png?v=1708944723","url":"https:\/\/afsbio.com\/products\/recombinant-human-abcg2-protein-his-tag-pdeh100426","provider":"AFSBio Inc.","version":"1.0","type":"link"}