{"product_id":"recombinant-human-ace-2-c-mfc-ept272","title":"Recombinant Human ACE-2 (C-mFc) - EPT272","description":"\u003cp\u003eRecombinant Human ACE-2 (C-mFc)\u003c\/p\u003e\n\n\u003cp\u003eSize: 50ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: EPT272-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a mFc tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9BYF1\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: 110 KDa\u003c\/p\u003e\n\n\u003cp\u003eApparent Molecular Weight: 110-140 KDa, reducing conditions\u003c\/p\u003e\n\n\u003cp\u003eStorage Condition: Lyophilized protein should be stored at \u0026lt; -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20°C for 3 months.\u003c\/p\u003e\n\n\u003cp\u003ePurity: Greater than 95% as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Less than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.\u003c\/p\u003e\n\n\u003cp\u003eBiological Activity: Immobilized 2019-nCoV S1 Protein (Cat#DRA35)at 10μg\/ml (100μl\/well) can bind Human ACE-2-mFc (Cat#C06A). The ED50 of Human ACE-2-mFc (Cat#C06A) is 45.11 ng\/ml.\u003c\/p\u003e\n\n\u003cp\u003eDelivery Condition: The product is shipped on dry ice\/polar packs. Upon receipt, store it immediately at the temperature listed below.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.\u003c\/p\u003e \n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"Default Title","offer_id":43211051106483,"sku":"EPT272-50","price":1020.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_1c2a35ae-7fa2-4f86-80b8-413432356b0c.png?v=1767117586","url":"https:\/\/afsbio.com\/products\/recombinant-human-ace-2-c-mfc-ept272","provider":"AFSBio Inc.","version":"1.0","type":"link"}