{"product_id":"recombinant-human-ace2-protein-mfc-tag-pksr030494","title":"Recombinant Human ACE2 Protein (mFc Tag) - PKSR030494","description":"\u003cp\u003eRecombinant Human ACE2 Protein (mFc Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSR030494-10, PKSR030494-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ACE2\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Cell biology; Cardiovascular\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-mFc\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9BYF1\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9BYF1\u003c\/p\u003e\n\n\u003cp\u003eBackground: Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized 2019-nCoV S1 Protein-Fc(Cat#PKSR030480) at 10μg\/ml (100 μl\/well) can bind Human ACE-2-mFc(Cat#PKSR030494). The ED50 of Recombinant Human ACE-2-mFc(Cat#PKSR030494) is 0.58 ug\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Gln18-Ser740\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μM filtered solution of 20 mM Tris-HCl, 300 mM NaCl, 1 mM ZnCl2, 10% Glycerol, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 110 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 110-140 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43118167031987,"sku":"PKSR030494-10","price":218.4,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43118167064755,"sku":"PKSR030494-50","price":655.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_613a07de-baf7-4d80-9f1a-586ef3d40b6e.png?v=1709637424","url":"https:\/\/afsbio.com\/products\/recombinant-human-ace2-protein-mfc-tag-pksr030494","provider":"AFSBio Inc.","version":"1.0","type":"link"}