{"product_id":"recombinant-human-activin-receptor-2b-acvr2b-protein-his-tag-pksh032040","title":"Recombinant Human Activin Receptor 2B\/ACVR2B Protein (His Tag) - PKSH032040","description":"\u003cp\u003eRecombinant Human Activin Receptor 2B\/ACVR2B Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032040-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Activin Receptor 2B; ACVR2B\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Activin Receptor Type-2B; Activin Receptor Type IIB; ACTR-IIB; ACVR2B; Bone Morphogenetic Protein Receptor Type-2; BMP Type-2 Receptor; BMPR-2; Bone Morphogenetic Protein Receptor Type II; BMP Type II Receptor\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q13705\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q13705\u003c\/p\u003e\n\n\u003cp\u003eBackground: Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily; exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine\/threonine kinase receptors. On ligand binding; type I and II receptors form a stable complex; resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity; and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB; also known as ActRIIB; is a type II receptor containing an extracellular domain (ECD); a transmembrane segment; and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A; activin B and inhibin A. Multiple ActRIIB isoforms can also be generated; which bind activin isoforms with different affinities.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ser19-Thr134\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 14.4 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 33 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μg","offer_id":43083650924723,"sku":"PKSH032040-50","price":249.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_5ba9f476-eb63-4589-9fb6-f7c2c867cddb.png?v=1708946222","url":"https:\/\/afsbio.com\/products\/recombinant-human-activin-receptor-2b-acvr2b-protein-his-tag-pksh032040","provider":"AFSBio Inc.","version":"1.0","type":"link"}