{"product_id":"recombinant-human-activin-riia-acvr2a-protein-fc-tagactive-pksh031729","title":"Recombinant Human Activin RIIA\/ACVR2A Protein (Fc Tag)(Active) - PKSH031729","description":"\u003cp\u003eRecombinant Human Activin RIIA\/ACVR2A Protein (Fc Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSize: 200μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSH031729-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Activin RIIA; ACVR2A\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Activin Receptor Type-2A; Activin Receptor Type IIA; ACTR-IIA; ACTRIIA; ACVR2A; ACVR2; ACTRII\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Signal Transduction; Cancer; metabolism; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: Cell culture\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-hFc\u003c\/p\u003e\n\n\u003cp\u003eAccession: NP_001607.1\u003c\/p\u003e\n\n\u003cp\u003eBackground: ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 10-40 ng\/mL in the presence of 10 ng\/mL recombinant Activin A.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Pro 134\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 97 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 40.0 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 60-65 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104323993779,"sku":"PKSH031729-200","price":1694.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_48977083-fcb5-4afd-ba79-ea3828ea8413.png?v=1709294308","url":"https:\/\/afsbio.com\/products\/recombinant-human-activin-riia-acvr2a-protein-fc-tagactive-pksh031729","provider":"AFSBio Inc.","version":"1.0","type":"link"}