{"product_id":"recombinant-human-activin-riib-acvr2b-protein-rp00153","title":"Recombinant Human Activin RIIB\/ACVR2B Protein - RP00153","description":"\u003cp\u003eRecombinant Human Activin RIIB\/ACVR2B Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00153-10, RP00153-20, RP00153-50, RP00153-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human Activin RIIB\/ACVR2B Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser19-Thr134) of human ACVR2B\/Activin RIIB (Accession #NP_001097.2) fused with an Fc, 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ACVR2B, ACTRIIB, ActR-IIB, HTX4\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q13705\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 93\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine\/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.\u003c\/p\u003e \n\n\u003cp\u003eBio-Activity: 1.Measured by its binding ability in a functional ELISA.Immobilized Human ACVR2B at 1 μg\/mL (100 μL\/well) can bind Human BMPRIA with a linear range of 0.5-62.5 ng\/mL.|2.Measured by its binding ability in a functional ELISA.Immobilized Human CD105 at 1 μg\/mL (100 μL\/well) can bind Human ACVR2B with a linear range of 0.49-43.03 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc\u0026amp;His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: SGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPT\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198297727155,"sku":"RP00153-10","price":182.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198297759923,"sku":"RP00153-20","price":217.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198297792691,"sku":"RP00153-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198297825459,"sku":"RP00153-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_9a972b4d-cb37-49a1-9006-c2b17d4ca775.png?v=1766960282","url":"https:\/\/afsbio.com\/products\/recombinant-human-activin-riib-acvr2b-protein-rp00153","provider":"AFSBio Inc.","version":"1.0","type":"link"}