{"product_id":"recombinant-human-akr1c4-protein-his-tag-pksh032056","title":"Recombinant Human AKR1C4 Protein (His Tag) - PKSH032056","description":"\u003cp\u003eRecombinant Human AKR1C4 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032056-10, PKSH032056-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: AKR1C4\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Aldo-Keto Reductase Family 1 Member C4; 3-Alpha-HSD1; 3-Alpha-Hydroxysteroid Dehydrogenase Type I; Chlordecone Reductase; CDR; Dihydrodiol Dehydrogenase 4; DD-4; DD4; HAKRA; AKR1C4; CHDR\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P17516\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cancer; metabolism;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P17516\u003c\/p\u003e\n\n\u003cp\u003eBackground: Aldo-Keto Reductase 1C4\/AKR1C4 is a member of the aldo\/keto reductase family that consists of more than 40 known enzymes and proteins. AKR1C4 has highly expressed in Liver. It can catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. AKR1C4 catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-α-Androstan-3-α, 17-β-diol (3-α-diol). In addition, AKR1C4 also has some 20-α-Hydroxysteroid Dehydrogenase activity.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Tyr323\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 39.3 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 26\u0026amp;38 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43083652333747,"sku":"PKSH032056-10","price":312.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43083652366515,"sku":"PKSH032056-50","price":830.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_a78fea51-2274-471b-a18f-0aec55e2a65f.png?v=1708946261","url":"https:\/\/afsbio.com\/products\/recombinant-human-akr1c4-protein-his-tag-pksh032056","provider":"AFSBio Inc.","version":"1.0","type":"link"}