{"product_id":"recombinant-human-alcam-cd166-protein-rp00119","title":"Recombinant Human ALCAM\/CD166 Protein - RP00119","description":"\u003cp\u003eRecombinant Human ALCAM\/CD166 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00119-10, RP00119-20, RP00119-50, RP00119-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human ALCAM\/CD166 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Met1-Ala526) of human ALCAM\/CD166 (Accession #NP_001618.2) fused with an Fc, 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ALCAM, CD166, MEMD, MEMD\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q13740\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 214\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This protein is activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found.\u003c\/p\u003e \n\n\u003cp\u003eBio-Activity: 1.Measured by its binding ability in a functional ELISA.Immobilized Human CD6 at 1 μg\/mL (100 μL\/well) can bind Human CD166 with a linear range of 0.05-1.2 ng\/mL.|2.Measured by its ability to block adhesion of Jurkat cells to immobilized Recombinant Human CD6 Protein. The ED50 for this effect is 2.7-10.8 μg\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc\u0026amp;His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: MESKGASSCRLLFCLLISATVFRPGLGWYTVNSAYGDTIIIPCRLDVPQNLMFGKWKYEKPDGSPVFIAFRSSTKKSVQYDDVPEYKDRLNLSENYTLSISNARISDEKRFVCMLVTEDNVFEAPTIVKVFKQPSKPEIVSKALFLETEQLKKLGDCISEDSYPDGNITWYRNGKVLHPLEGAVVIIFKKEMDPVTQLYTMTSTLEYKTTKADIQMPFTCSVTYYGPSGQKTIHSEQAVFDIYYPTEQVTIQVLPPKNAIKEGDNITLKCLGNGNPPPEEFLFYLPGQPEGIRSSNTYTLTDVRRNATGDYKCSLIDKKSMIASTAITVHYLDLSLNPSGEVTRQIGDALPVSCTISASRNATVVWMKDNIRLRSSPSFSSLHYQDAGNYVCETALQEVEGLKKRESLTLIVEGKPQIKMTKKTDPSGLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSKIIISPEENVTLTCTAENQLERTVNSLNVSAISIPEHDEADEISDENREKVNDQA\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198295072947,"sku":"RP00119-10","price":140.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198295105715,"sku":"RP00119-20","price":154.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198295138483,"sku":"RP00119-50","price":168.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198295171251,"sku":"RP00119-100","price":280.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_a1bdce50-cba2-44cc-a06f-b957c5a8756c.png?v=1766960247","url":"https:\/\/afsbio.com\/products\/recombinant-human-alcam-cd166-protein-rp00119","provider":"AFSBio Inc.","version":"1.0","type":"link"}