{"product_id":"recombinant-human-alk-2-acvr1-protein-his-fc-tagactive-pksh031744","title":"Recombinant Human ALK-2\/ACVR1 Protein (His \u0026 Fc Tag)(Active) - PKSH031744","description":"\u003cp\u003eRecombinant Human ALK-2\/ACVR1 Protein (His \u0026amp; Fc Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSize: 200μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSH031744-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ALK-2; ACVR1\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Activin Receptor Type-1; Activin Receptor Type I; ACTR-I; Activin Receptor-Like Kinase 2; ALK-2; Serine\/Threonine-Protein Kinase Receptor R1; SKR1; TGF-B Superfamily Receptor Type I; TSR-I; ACVR1; ACVRLK2; ACVR1A; ACVRLK2; ALK2; FOP; SKR1\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Signal Transduction; epigenetics and nuclear signal; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His \u0026amp; Fc\u003c\/p\u003e\n\n\u003cp\u003eAccession: NP_001104537.1\u003c\/p\u003e\n\n\u003cp\u003eBackground: ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been demonstrated that ALK-2 forms complex with either the BMP-2\/7-bound BMPR-II or ACVR2A \/ACVR2B. ALK-1 and ALK-2 presenting in the yeast Saccharomyces cerevisiae are two haspin homologues. Both ALK-1 and ALK-2 exhibit a weak auto-kinase activity in vitro, and are phosphoproteins in vivo. ALK-1 and ALK-2 levels peak in mitosis and late-S\/G2. Control of protein stability plays a major role in ALK-2 regulation. The half-life of ALK-2 is particularly short in G1. Overexpression of ALK-2, but not of ALK-1, causes a mitotic arrest, which is correlated to the kinase activity of the protein. This suggests a role for ALK-2 in the control of mitosis. Endoglin is phosphorylated on cytosolic domain threonine residues by the TGF-beta type I receptors ALK-2 and ALK-5 in prostate cancer cells. Endoglin did not inhibit cell migration in the presence of constitutively active ALK-2. Defects in ALK-2 are a cause of fibrodysplasia ossificans progressiva (FOP).\u003c\/p\u003e\n\n\u003cp\u003eActivity: Measure by its ability to bind with human BMP2 in a functional ELISA.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Val 124\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 39.6 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 40-45 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104324616371,"sku":"PKSH031744-200","price":1694.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_69ac882d-2edc-4f80-bf7d-d94035ac0f6d.png?v=1709294323","url":"https:\/\/afsbio.com\/products\/recombinant-human-alk-2-acvr1-protein-his-fc-tagactive-pksh031744","provider":"AFSBio Inc.","version":"1.0","type":"link"}