{"product_id":"recombinant-human-alk-4-acvr1b-protein-rp00074","title":"Recombinant Human ALK-4\/ACVR1B Protein - RP00074","description":"\u003cp\u003eRecombinant Human ALK-4\/ACVR1B Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: RP00074-50, RP00074-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human ALK-4\/ACVR1B Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met 1-Glu 126) of human ACVR1B (Accession #NP_004293.1) fused with a C-hFc＆his at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ACTRIB, ACVRLK4, ALK4, SKR2, ACVR1B, ACVRLK4, ALK4, SKR2\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P36896-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 91\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser\/Thr protein kinase family, and TGFB receptor subfamily. ALK-4\/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4\/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ACVR1B at 0.5 μg\/mL (100 μL\/well) can bind Human ACVR2B with a linear range of 2.0-286.1 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc＆his\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVE\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"50ug","offer_id":45198361198771,"sku":"RP00074-50","price":168.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198361231539,"sku":"RP00074-100","price":280.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_2c0a5de8-64d1-49a4-b3e4-b3bcc3f300c3.png?v=1766961181","url":"https:\/\/afsbio.com\/products\/recombinant-human-alk-4-acvr1b-protein-rp00074","provider":"AFSBio Inc.","version":"1.0","type":"link"}