{"product_id":"recombinant-human-alk4-acvr1b-protein-his-tagactive-pksh032037","title":"Recombinant Human ALK4\/ACVR1B Protein (His Tag)(Active) - PKSH032037","description":"\u003cp\u003eRecombinant Human ALK4\/ACVR1B Protein (His Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSH032037-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ALK4; ACVR1B\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Activin Receptor Type-1B; Activin Receptor Type IB; ACTR-IB; Activin Receptor-Like Kinase 4; ALK-4; Serine\/Threonine-Protein Kinase Receptor R2; SKR2; ACVR1B; ACVRLK4; ALK4\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Signal Transduction; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P36896\u003c\/p\u003e\n\n\u003cp\u003eAccession: P36896\u003c\/p\u003e\n\n\u003cp\u003eBackground: Activin Receptor Type-1B (ACVR1B) is a single-pass type I membrane protein that belongs to the protein kinase superfamily. ACVR1B contains one GS domain and one protein kinase domain and is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B, ACVR2A or ACVR2B activating ACVR1B through phosphorylation of its regulatory GS domain. They go on to recruit the R-SMADs, SMAD2 and SMAD3. ACVR1B also transducers signals of nodal, GDF-1, and Vg1. Mutations in ACVR1B are associated with pituitary tumors.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized Human TDGF1-Fc(Cat: PKSH033100) at 10μg\/ml(100 μl\/well) can bind Human ACVR1B-His. The ED50 of Human ACVR1B-His is 4. 7 ug\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ser24-Glu126\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 12.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 18 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43107262693555,"sku":"PKSH032037-50","price":180.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_a9efef26-13f2-4885-a01c-e12971cb0ff7.png?v=1709382117","url":"https:\/\/afsbio.com\/products\/recombinant-human-alk4-acvr1b-protein-his-tagactive-pksh032037","provider":"AFSBio Inc.","version":"1.0","type":"link"}