{"product_id":"recombinant-human-alpha-synuclein-snca-protein-active-pksh033771","title":"Recombinant Human Alpha-Synuclein\/SNCA Protein (Active) - PKSH033771","description":"Recombinant Human Alpha-Synuclein\/SNCA Protein (Active)\n\nSize: 50μg\n\nCatalogue Number: PKSH033771-50\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: SNCA\n\nTarget Symptom: Alpha-Synuclein; Non-A Beta Component of AD Amyloid; Non-A4 Component of Amyloid Precursor; NACP; SNCA; NACP; PARK1\n\nResearch Area: Neuroscience\n\nTarget Species: Human\n\nExpression Host: E.coli\n\nFusion Tag: None\n\nUNIProt ID: P37840\n\nAccession: P37840\n\nBackground: Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1; Phospholipase D and histones. SNCA can include beta- and gamma-synuclein. In addition; SNCA is an important regulatory component of vesicular transport in neuronal cells. It has been suggested that SNCA is related to the pathogenesis of Parkinson' s Disease and neurodegenerative disorders. Defects in SNCA will lead to Dementia Lewy Body (DLB).\n\nActivity: Recombinant Human alpha -Synuclein is ideal for use as a control substrate for in vitro Ubiquitin conjugation using select Ubiquitin E3 ligases such as CHIP\/Stub1. Aggregation T1\/2 time of 70 µM human alpha -Synuclein protein is 1.07h(0.5 mM SDS).\n\nSequence: Met1-Ala140\n\nPurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from a 0.2 μm filtered solution of PBS; PH7.4.\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 14.46 kDa\n\nObserved MW: 17 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104343851187,"sku":"PKSH033771-50","price":155.4,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_7ebc4b9a-3241-4ba6-9077-c79d37cdd780.png?v=1709294776","url":"https:\/\/afsbio.com\/products\/recombinant-human-alpha-synuclein-snca-protein-active-pksh033771","provider":"AFSBio Inc.","version":"1.0","type":"link"}