{"product_id":"recombinant-human-ampk1-protein-gst-tag-pdeh100136","title":"Recombinant Human AMPK1 protein (GST tag) - PDEH100136","description":"\u003cp\u003eRecombinant Human AMPK1 protein (GST tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDEH100136-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: AMPK1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: PRKAA1; AMPK1; AMPK subunit alpha-1; PRKAA1; ACACA kinase; PRKAA1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q13131\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Neuroscience; Signal Transduction; Cardiovascular; Cancer; Metabolism\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-GST\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q13131-2\u003c\/p\u003e\n\n\u003cp\u003eBackground: AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic alpha subunit and regulatory beta and gamma subunits. Each subunit exists as alternate isoforms ( alpha 1, alpha 2, beta 1, beta 2, gamma 1, gamma 2, gamma 3), with all 12 combinations able to form complexes. The catalytic alpha subunit of AMPK is activated allosterically by AMP, and by phosphorylation via the AMPK kinases LKB1 and CaMKK beta. AMPK’s role in metabolic regulation has implicated this serine\/threonine kinase as a therapeutic target in heart disease, obesity, and diabetes.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Lys 421-Gln 574\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 41.83 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 45 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43072322699443,"sku":"PDEH100136-100","price":165.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_16edcb13-e6f9-4814-b00a-68293dfd038f.png?v=1708685465","url":"https:\/\/afsbio.com\/products\/recombinant-human-ampk1-protein-gst-tag-pdeh100136","provider":"AFSBio Inc.","version":"1.0","type":"link"}