{"product_id":"recombinant-human-angiopoietin-1-ang1-n-fc-pksh033955","title":"Recombinant Human Angiopoietin-1\/ANG1 (N-Fc) - PKSH033955","description":"\u003cp\u003eRecombinant Human Angiopoietin-1\/ANG1 (N-Fc)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033955-10, PKSH033955-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Angiopoietin-1; ANG1\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: AGP1; AGPT; Ang1; ANG-1; angiopoietin 1; Angiopoietin-1; ANGPT1\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Cardiovascular; Cancer; metabolism\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-Fc\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q15389\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q15389\u003c\/p\u003e\n\n\u003cp\u003eBackground: Angiopoietin-1 (Ang-1) is a secreted glycoprotein that plays a critical role in the development and maintenance of the vascular system. The angiopoietin (ANGPT)-TIE2\/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist\/antagonist. Angiopoietin-1 can protect against pulmonary arterial hypertension, reduce the extent of fibrosis and remodeling in infarcted diabetic myocardium, and enhance tumor progression and metastasis.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Asp256-Phe498\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 53.9 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 55-65 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43114006380723,"sku":"PKSH033955-10","price":249.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43114006413491,"sku":"PKSH033955-50","price":743.4,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_fee0310f-ba77-42a7-8d26-6306c42a00bd.png?v=1709550100","url":"https:\/\/afsbio.com\/products\/recombinant-human-angiopoietin-1-ang1-n-fc-pksh033955","provider":"AFSBio Inc.","version":"1.0","type":"link"}