{"product_id":"recombinant-human-angiopoietin-like-3-angptl317-460-protein-rp02866","title":"Recombinant Human Angiopoietin-like 3\/ANGPTL3(17-460) Protein - RP02866","description":"\u003cp\u003eRecombinant Human Angiopoietin-like 3\/ANGPTL3(17-460) Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP02866-10, RP02866-20, RP02866-50, RP02866-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human Angiopoietin-like 3\/ANGPTL3(17-460) Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser17-Glu460) of human Angiopoietin-like 3\/ANGPTL3 (Accession #NP_055310.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ANG-5, ANGPT5, ANL3, FHBL2, ANGPTL3, ANGPT5, ANL3, FHBL2, ANGPTL3\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q9Y5C1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 27329\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90% as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Angiopoietin-like protein 3 (ANGPTL3) also known as Angiopoietin-related protein 3, Angiopoietin-5 (ANG-5) is a secreted glycoprotein that is structurally related to the angiopoietins.Human ANGPTL3 contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. The fibrinogen C-terminal domain is sufficient to mediate endothelial cell adhesion. ANGPTL3 is principally expressed in the liver and can exert activities related to both angiogenesis and lipid metabolism.ANGPTL3 directly inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), enzymes responsible for hydrolyzing circulating triglycerides and HDL phospholipids.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, 0.05% CHAPS, pH7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: SRIDQDNSSFDSLSPEPKSRFAMLDDVKILANGLLQLGHGLKDFVHKTKGQINDIFQKLNIFDQSFYDLSLQTSEIKEEEKELRRTTYKLQVKNEEVKNMSLELNSKLESLLEEKILLQQKVKYLEEQLTNLIQNQPETPEHPEVTSLKTFVEKQDNSIKDLLQTVEDQYKQLNQQHSQIKEIENQLRRTSIQEPTEISLSSKPRAPRTTPFLQLNEIRNVKHDGIPAECTTIYNRGEHTSGMYAIRPSNSQVFHVYCDVISGSPWTLIQHRIDGSQNFNETWENYKYGFGRLDGEFWLGLEKIYSIVKQSNYVLRIELEDWKDNKHYIEYSFYLGNHETNYTLHLVAITGNVPNAIPENKDLVFSTWDHKAKGHFNCPEGYSGGWWWHDECGENNLNGKYNKPRAKSKPERRRGLSWKSQNGRLYSIKSTKMLIHPTDSESFE\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198275051699,"sku":"RP02866-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198275084467,"sku":"RP02866-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198275117235,"sku":"RP02866-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198275150003,"sku":"RP02866-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_554d7fe3-a054-42b9-9cf0-39e06491ab8e.png?v=1766960001","url":"https:\/\/afsbio.com\/products\/recombinant-human-angiopoietin-like-3-angptl317-460-protein-rp02866","provider":"AFSBio Inc.","version":"1.0","type":"link"}