{"product_id":"recombinant-human-apolipoprotein-a-i-apoai-protein-his-tag-e-coli-pksh032081","title":"Recombinant Human Apolipoprotein A-I\/ApoAI Protein (His Tag, E. coli) - PKSH032081","description":"\u003cp\u003eRecombinant Human Apolipoprotein A-I\/ApoAI Protein (His Tag, E. coli)\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032081-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Apolipoprotein A-I; ApoAI\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Apolipoprotein A-I; Apo-AI; ApoA-I; Apolipoprotein A1; APOA1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P02647\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cardiovascular; Neuroscience; Cancer; metabolism;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P02647\u003c\/p\u003e\n\n\u003cp\u003eBackground: Apolipoprotein A1 (APOA1) is a secreted protein which belongs to the Apolipoprotein A1\/A4\/E family. APOA1 is the major protein component of high density lipoprotein (HDL) in plasma. APOA1 plays a critical role in various biological processes; such as Cholesterol metabolism; Lipid metabolism and transport; Steroid metabolism. APOA1 promotes cholesterol efflux from tissues to the liver and thus helps to clear cholesterol from arteries. Defects in this gene resulted in HDL deficiencies; including Tangier disease (TGD); systemic non-neuropathic amyloidosis; premature coronary artery disease; hepatosplenomegaly and progressive muscle wasting and weakness. In addition; ApoA-I is implicated in the anti-endotoxin function of HDL via interaction with lipopolysaccharide or endotoxin.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Arg19-Gln267\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 30.2 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 28 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μg","offer_id":43083654922419,"sku":"PKSH032081-50","price":180.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_2adf6b2d-dd76-4792-9b2d-f2c025d418cc.png?v=1708946322","url":"https:\/\/afsbio.com\/products\/recombinant-human-apolipoprotein-a-i-apoai-protein-his-tag-e-coli-pksh032081","provider":"AFSBio Inc.","version":"1.0","type":"link"}