{"product_id":"recombinant-human-arresten-col4α1-protein-his-tag-pdmh100086","title":"Recombinant Human Arresten\/COL4α1 protein (His tag) - PDMH100086","description":"\u003cp\u003eRecombinant Human Arresten\/COL4α1 protein (His tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDMH100086-20, PDMH100086-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Arresten; COL4α1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Collagen alpha-1(IV) chain; COL4A1; Arresten\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P02462\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P02462\u003c\/p\u003e\n\n\u003cp\u003eBackground: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin\/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ser1441-Thr1669\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 25.08 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 30 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43083619467443,"sku":"PDMH100086-20","price":418.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43083619500211,"sku":"PDMH100086-100","price":698.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_5c1e81e1-c892-4958-bc76-4f2150835f44.png?v=1708945354","url":"https:\/\/afsbio.com\/products\/recombinant-human-arresten-col4%ce%b11-protein-his-tag-pdmh100086","provider":"AFSBio Inc.","version":"1.0","type":"link"}