{"product_id":"recombinant-human-atf2-protein-his-gst-tag-pksh031071","title":"Recombinant Human ATF2 Protein (His \u0026 GST Tag) - PKSH031071","description":"\u003cp\u003eRecombinant Human ATF2 Protein (His \u0026amp; GST Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSH031071-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ATF2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CRE-BP1, CREB-2, CREB2, HB16, TREB7\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P15336\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: Baculovirus-Insect Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His \u0026amp; GST\u003c\/p\u003e\n\n\u003cp\u003eAccession: P15336-1\u003c\/p\u003e\n\n\u003cp\u003eBackground: Activating transcription factor 2, also known as ATF2, is a member of the leucine zipper family of DNA-binding proteins that binds to the cAMP response element. Its activity is enhanced after phosphorylation by stress-activated protein kinases such as c-Jun N-terminal kinase and p38. ATF2 has been found to be a target of the JNK signal transduction pathway and mediate adenovirus E1A-inducible transcriptional activation. ATF2 is also been reported playing roles in TGF-\u0026amp;beta, signaling pathway. It has been shown that the transcription factor ATF2 is bound by a hetero-oligomer of Smad3 and Smad4 upon TGF-\u0026amp;beta, stimulation. Studies indicate that ATF-2 plays a central role in TGF-\u0026amp;beta, signaling by acting as a common nuclear target of both Smad and TAK1 pathways.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Ser 505\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 10% glycerol\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 82.4 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 85 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43155075399859,"sku":"PKSH031071-100","price":1505.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_5d35e431-dfc3-4e9f-b29c-f53e52334418.png?v=1710438525","url":"https:\/\/afsbio.com\/products\/recombinant-human-atf2-protein-his-gst-tag-pksh031071","provider":"AFSBio Inc.","version":"1.0","type":"link"}