{"product_id":"recombinant-human-b7-2-cd86-protein-rp00090","title":"Recombinant Human B7-2\/CD86 Protein - RP00090","description":"\u003cp\u003eRecombinant Human B7-2\/CD86 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00090-10, RP00090-20, RP00090-50, RP00090-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human B7-2\/CD86 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Leu26-Pro247) of human CD86\/B7-2 (Accession #NP_008820.2) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: B7-2, B7.2, B70, CD28LG2, LAB72, CD86, B7-2, B7.2, B70, CD28LG2, LAB72, CD86 molecule\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P42081\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 942\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. CD86 is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human CD86 at 2 μg\/mL (100 μL\/well) can bind Recombinant Human CTLA-4 with a linear range of 10-40 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: LKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHIP\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198297596083,"sku":"RP00090-10","price":182.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198297628851,"sku":"RP00090-20","price":217.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198297661619,"sku":"RP00090-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198297694387,"sku":"RP00090-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_a79b7a6f-b3ed-4b59-94cd-e8a7973f748c.png?v=1766960281","url":"https:\/\/afsbio.com\/products\/recombinant-human-b7-2-cd86-protein-rp00090","provider":"AFSBio Inc.","version":"1.0","type":"link"}