{"product_id":"recombinant-human-b7-dc-pd-l2-cd273-protein-rp00988","title":"Recombinant Human B7-DC\/PD-L2\/CD273 Protein - RP00988","description":"\u003cp\u003eRecombinant Human B7-DC\/PD-L2\/CD273 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00988-10, RP00988-20, RP00988-50, RP00988-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human PD-L2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu20-Pro219) of human PD-L2 (Accession #NP_079515.2) fused with an Fc, 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: B7DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2, bA574F11.2, PDCD1LG2\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q9BQ51\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 80380\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Programmed Death Ligand 2 (PD-L2), also known as B7-DC and butyrophilin-like protein, is a member of the B7 family of proteins that provide signals for regulating T-cell activation and tolerance.PD-L2 is expressed on dendritic cells, subsets of activated CD4+ and CD8+ T cells, and memory B cells that differentiate into plasma cells. At inflammatory sites such as rheumatoid arthritis, allergen exposure, and virus infection, PD-L2 is up-regulated on synoviocytes, infiltrating macrophages, dendritic cells, and airway epithelial cells. PD-L2, along with B7-H1\/PD-L1, binds to T cell PD-1 where it promotes IFN-gamma production and CD40 Ligand up-regulation while inhibiting IL-4 production. In addition, PD-L2 binds to RGM-B on macrophages and alveolar epithelial cells, supporting respiratory immune tolerance. In asthma, PD-L2 suppresses IL-5 and IL-13 production, promotes IL-12 production by dendritic cells, and supports allergen-induced airway hyper-responsiveness and mucus production.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human PD-1 at 5 μg\/mL (100 μL\/well) can bind Recombinant Human PD-L2 with a linear range of 0.06-0.24 μg\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc\u0026amp;His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: LFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQKVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVKASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHP\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198315094195,"sku":"RP00988-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198315126963,"sku":"RP00988-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198315159731,"sku":"RP00988-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198315192499,"sku":"RP00988-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_1e854149-d805-444c-98e5-9b3f90df02a6.png?v=1766960507","url":"https:\/\/afsbio.com\/products\/recombinant-human-b7-dc-pd-l2-cd273-protein-rp00988","provider":"AFSBio Inc.","version":"1.0","type":"link"}