{"product_id":"recombinant-human-b7-h2-icoslg-cd275-protein-rp00385","title":"Recombinant Human B7-H2\/ICOSLG\/CD275 Protein - RP00385","description":"\u003cp\u003eRecombinant Human B7-H2\/ICOSLG\/CD275 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00385-10, RP00385-20, RP00385-50, RP00385-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human B7-H2\/ICOSLG\/CD275 Protein is produced by Human Cell expression system. The target protein is expressed with sequence (Asp19-Ser258) of human ICOSLG\/B7-H2\/CD275 (Accession #O75144) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS\u003c\/p\u003e\n\n\u003cp\u003eSWISS: O75144\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 23308\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Inducible co-stimulator ligand (ICOSL) is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28\/B7 and ICOS\/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: N-hFC\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: DTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAAT\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.01 EU\/μg of the protein by LAL method\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198238023859,"sku":"RP00385-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198238056627,"sku":"RP00385-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198238089395,"sku":"RP00385-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198238122163,"sku":"RP00385-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_f1244735-ff29-4e24-8f6e-542619f0dcb1.png?v=1766959584","url":"https:\/\/afsbio.com\/products\/recombinant-human-b7-h2-icoslg-cd275-protein-rp00385","provider":"AFSBio Inc.","version":"1.0","type":"link"}