{"product_id":"recombinant-human-bace-1-asp2-protein-rp00165","title":"Recombinant Human BACE-1\/ASP2 Protein - RP00165","description":"\u003cp\u003eRecombinant Human BACE-1\/ASP2 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00165-10, RP00165-20, RP00165-50, RP00165-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human BACE-1\/ASP2 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Thr22-Tyr460) of human BACE1\/ASP2 (Accession #NP_036236.1) fused with an 8×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ASP2, BACE, HSPC104, BACE1, BACE, HSPC104\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P56817\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 23621\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells.BACE-1 is the peptidase predominantly responsible for cleavage of the amyloid precursor protein beta site in the brain to generate the amyloid beta peptide. Because the amyloid beta peptide is a major component of amyloid plaques, BACE-1 has been implicated in the onset and\/or progression of Alzheimer's disease. BACE-1 is expressed in a variety of human tissues,such brain, pancreatic tissue.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its ability to cleave a fluorogenic peptide substrate, Mca-SEVNLDAEFRK(Dpn)RR-NH2. The specific activity is \u0026gt;5.5 pmol\/min\/μg.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: TQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAY\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198308081843,"sku":"RP00165-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198308114611,"sku":"RP00165-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198308147379,"sku":"RP00165-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198308180147,"sku":"RP00165-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_1f4887eb-78be-455c-8d5d-44456cfb6309.png?v=1766960425","url":"https:\/\/afsbio.com\/products\/recombinant-human-bace-1-asp2-protein-rp00165","provider":"AFSBio Inc.","version":"1.0","type":"link"}