{"product_id":"recombinant-human-bcl2l1-bcl-xl-protein-his-tag-pksh033757","title":"Recombinant Human BCL2L1\/Bcl-XL Protein (His Tag) - PKSH033757","description":"\u003cp\u003eRecombinant Human BCL2L1\/Bcl-XL Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033757-10, PKSH033757-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: BCL2L1; Bcl-XL\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Bcl-2-Like Protein 1; Bcl2-L-1; Apoptosis Regulator Bcl-X; Bcl-X; bcl-xL; BCL-XL\/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Signal Transduction; Cell biology; Cancer; metabolism;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q07817\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q07817\u003c\/p\u003e\n\n\u003cp\u003eBackground: Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met1-Arg212\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM HEPES, 50mM KCl, 20% Glycerol, pH 7.5.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 24.85 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 29 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43113988096179,"sku":"PKSH033757-10","price":385.0,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43113988128947,"sku":"PKSH033757-50","price":735.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_a5f43912-8bb8-49f8-adeb-326ea6fc24a9.png?v=1709549744","url":"https:\/\/afsbio.com\/products\/recombinant-human-bcl2l1-bcl-xl-protein-his-tag-pksh033757","provider":"AFSBio Inc.","version":"1.0","type":"link"}