{"product_id":"recombinant-human-bcma-tnfrsf17-protein-mfc-tag-pksh033485","title":"Recombinant Human BCMA\/TNFRSF17 Protein (mFc Tag) - PKSH033485","description":"\u003cp\u003eRecombinant Human BCMA\/TNFRSF17 Protein (mFc Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033485-10, PKSH033485-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: BCMA; TNFRSF17\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269; Tnfrsf17; Bcm; Bcma\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Signal Transduction; Cancer; immunology;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-mFc\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q02223\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q02223\u003c\/p\u003e\n\n\u003cp\u003eBackground: B cell maturation antigen (BCMA) is a member of the TNF receptor superfamily. It has been designated TNFRSF17. Mouse BCMA is a 185 amino acid (aa) protein consisting of a 49 aa extracellular domain; a 23 aa transmembrane domain; and a 113 aa intracellular domain. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF; it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF; members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface; BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development; function and regulation.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met1-Ala54\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 32.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 35-42 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43113962012851,"sku":"PKSH033485-10","price":201.6,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43113962045619,"sku":"PKSH033485-50","price":582.4,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_0226221f-7abb-48ff-baae-0302941a85a7.png?v=1709549231","url":"https:\/\/afsbio.com\/products\/recombinant-human-bcma-tnfrsf17-protein-mfc-tag-pksh033485","provider":"AFSBio Inc.","version":"1.0","type":"link"}