{"product_id":"recombinant-human-beta-2-microglobulin-b2m-protein-hek293-cells-his-tag-pksh030949","title":"Recombinant Human Beta-2-Microglobulin\/B2M Protein (HEK293 Cells, His Tag) - PKSH030949","description":"\u003cp\u003eRecombinant Human Beta-2-Microglobulin\/B2M Protein (HEK293 Cells, His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSH030949-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Beta-2-Microglobulin, B2M\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Beta-2-Microglobulin, B2M, β2-Microglobulin\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cardiovascular, Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: NP_004039.1\u003c\/p\u003e\n\n\u003cp\u003eBackground: B2M, also known as \u0026amp;beta, 2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(\u0026amp;beta, 2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(\u0026amp;beta, 2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M(\u0026amp;beta, 2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to the\u0026amp;alpha, 3 chain. Unlike\u0026amp;alpha, 3, \u0026amp;beta, 2 has no transmembrane region. Directly above \u0026amp;beta, 2 lies the \u0026amp;alpha, 1 chain, which itself is lateral to the \u0026amp;alpha, 2. In the absence of B2M(\u0026amp;beta, 2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M(\u0026amp;beta, 2 microglobulin) can indicate non-progression of HIV.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Met 119\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 97 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 13.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 13.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43155027919027,"sku":"PKSH030949-100","price":749.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_e56e00ef-ee4c-4ca4-a55b-e231e12ab296.png?v=1710436854","url":"https:\/\/afsbio.com\/products\/recombinant-human-beta-2-microglobulin-b2m-protein-hek293-cells-his-tag-pksh030949","provider":"AFSBio Inc.","version":"1.0","type":"link"}