{"product_id":"recombinant-human-betacellulin-btc-protein-rp01700","title":"Recombinant Human Betacellulin\/BTC Protein - RP01700","description":"\u003cp\u003eRecombinant Human Betacellulin\/BTC Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01700-10, RP01700-20, RP01700-50, RP01700-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human Betacellulin\/BTC Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp32-Tyr111) of human Betacellulin\/BTC (Accession #NP_001720.1) fused with and a hFc tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: BTC; Betacellulin\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P35070\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 685\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Betacellulin(BTC) is a member of the epidermal growth factor (EGF) family. These soluble proteins are ligands for one or more of the four receptor tyrosine kinases encoded by the ErbB gene family (ErbB-1\/epidermal growth factor receptor (EGFR), neu\/ErbB-2\/HER2, ErbB-3\/HER3 and ErbB-4\/HER4). Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. This protein is a ligand for the EGF receptor. BTC is a polymer of about 62-111 amino acid residues. Secondary Structure: 6% helical (1 helices; 3 residues)36% beta sheet (5 strands; 18 residues). BTC was originally identified as a growth-promoting factor in mouse pancreatic β-cell carcinoma cell line and has since been identified in humans. It plays a role in the growth and development of the neonate and\/or mammary gland function. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured in a cell proliferation assay using BALB\/3T3 mouse fibroblasts. The ED50 for this effect is 1.02-4.06 ng\/mL, corresponding to a specific activity of 2.46×10^5 ~9.80×10^5 units\/mg.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: DGNSTRSPETNGLLCGDPEENCAATTTQSKRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFY\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198321549491,"sku":"RP01700-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198321582259,"sku":"RP01700-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198321615027,"sku":"RP01700-50","price":350.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198321647795,"sku":"RP01700-100","price":560.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_81c8aca0-260d-47fc-9456-f6cd26e859fe.png?v=1766960582","url":"https:\/\/afsbio.com\/products\/recombinant-human-betacellulin-btc-protein-rp01700","provider":"AFSBio Inc.","version":"1.0","type":"link"}