{"product_id":"recombinant-human-biglycan-bgn-protein-his-tag-pdmh100070","title":"Recombinant Human Biglycan\/BGN protein (His tag) - PDMH100070","description":"\u003cp\u003eRecombinant Human Biglycan\/BGN protein (His tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDMH100070-20, PDMH100070-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Biglycan; BGN\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Biglycan; Bone\/Cartilage Proteoglycan I; PG-S1; BGN; SLRR1A\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P21810\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P21810\u003c\/p\u003e\n\n\u003cp\u003eBackground: Biglycan is a 200-350 kD proteoglycan consisting of a 45 kD core protein and two chrondroitin\/dermatan sulfate glycosaminoglycan chains. Biglycan binds to TGF--. It also binds to collagen type I in low ionic strength (less than 3 mM phosphate) buffer. At higher ionic strengths, Biglycan does not bind to collagen type I. It enhances the inhibition effect of TGF-- on osteoclast proliferation at a concentration of 4-20 mg\/ml. It also prevents the attachment of CHO cells to fibronectin, with a 50% inhibition at 17-21 mg\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Glu20-Lys368\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 40.37 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 42 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43083615731891,"sku":"PDMH100070-20","price":502.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43083615764659,"sku":"PDMH100070-100","price":838.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_7e98e975-cf20-4a84-8824-8ebdbebb7362.png?v=1708945294","url":"https:\/\/afsbio.com\/products\/recombinant-human-biglycan-bgn-protein-his-tag-pdmh100070","provider":"AFSBio Inc.","version":"1.0","type":"link"}