{"product_id":"recombinant-human-bmpr2-protein-fc-his-tag-pksh032121","title":"Recombinant Human BMPR2 Protein (Fc \u0026 His Tag) - PKSH032121","description":"\u003cp\u003eRecombinant Human BMPR2 Protein (Fc \u0026amp; His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032121-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: BMPR2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1; T-ALK\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q13873\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cardiovascular; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-Fc-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q13873\u003c\/p\u003e\n\n\u003cp\u003eBackground: Bone Morphogenetic Protein Receptor II (BMPR-II) is a Type II Serine\/Threonine Kinase that mediates cellular responses to BMPs. BMPR-II is characterized by lacking of a GS domain, and presence of a C-terminal extension typical of type II receptors. BMPRII binds BMP2, BMP4 and BMP7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor, including BMPR-IA\/Brk1, BMPR-IB, and ActR-I. BMPR-II plays a key role in cell growth. Defects in BMPR-II have been linked to primary pulmonary hypertension. Human and mouse BMPR-II are highly conserved and share 97 % amino acid sequence identity.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ser27-Ile151\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 41.9 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 60-70 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μg","offer_id":43083658100915,"sku":"PKSH032121-50","price":249.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_d4049ce8-2eac-4fb1-affd-b312f4ad89bc.png?v=1708946411","url":"https:\/\/afsbio.com\/products\/recombinant-human-bmpr2-protein-fc-his-tag-pksh032121","provider":"AFSBio Inc.","version":"1.0","type":"link"}