{"product_id":"recombinant-human-calnexin-canx-protein-his-tag-pdmh100065","title":"Recombinant Human Calnexin\/CANX protein (His tag) - PDMH100065","description":"\u003cp\u003eRecombinant Human Calnexin\/CANX protein (His tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDMH100065-20, PDMH100065-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Calnexin; CANX\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Calnexin; IP90; Major Histocompatibility Complex Class I Antigen-Binding Protein p88; p90; CANX\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P27824\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Tags \u0026amp; Cell Markers; Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P27824\u003c\/p\u003e\n\n\u003cp\u003eBackground: Calnexin\/CANX is a single-pass type I membrane protein which belongs to the calreticulin family. It consists of a large N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail. The function of calnexin is to retain unfolded or unassembled N-linked glycoproteins in the endoplasmic reticulum. Calnexin is a calcium-binding protein that interacts briefly with newly synthesized glycoproteins in the endoplasmic reticulum. Calnexin may act in assisting protein assembly and\/or in the retention within the ER of unassembled protein subunits. Calnexin seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Calnexin dwindles with aging and might contribute to a cytoprotection in an array of human age-related diseases.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met1-Pro481\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 52.8 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 60 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43083614486707,"sku":"PDMH100065-20","price":264.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43083614519475,"sku":"PDMH100065-100","price":418.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_e68c9771-2f40-4925-8fa0-f8fbf11d2e66.png?v=1708945273","url":"https:\/\/afsbio.com\/products\/recombinant-human-calnexin-canx-protein-his-tag-pdmh100065","provider":"AFSBio Inc.","version":"1.0","type":"link"}