{"product_id":"recombinant-human-camk2a-camka-protein-gst-tagactive-pksh030403","title":"Recombinant Human CAMK2A\/CAMKA Protein (GST Tag)(Active) - PKSH030403","description":"\u003cp\u003eRecombinant Human CAMK2A\/CAMKA Protein (GST Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSH030403-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CAMK2A; CAMKA\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: CAMKA\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Signal Transduction; Cardiovascular; Neuroscience; Cancer; metabolism;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: Baculovirus-Insect Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: Enzyme\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-GST\u003c\/p\u003e\n\n\u003cp\u003eAccession: NP_741960.1\u003c\/p\u003e\n\n\u003cp\u003eBackground: Ca2+\/calmodulin-dependent protein kinase2A (CAMK2A) belongs to the serine\/threonine protein kinase family and, together with other 28 different isoforms, belongs to the Ca2+\/ calmodulin-dependent protein kinase subfamily. CaM kinase Ⅱ is thought to be an important mediator of learning and memory and is also necessary for Ca2+ homeostasis and reuptake in cardiomyocytes chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CAMKIIA is one of the major forms of CAMKII. It has been found to play a critical role in sustaining activation of CAMKII at the postsynaptic density. Studies have found that knockout mice without CAMKIIA demonstrate a low frequency of LTP. Additionally, these mice do not form persistent, stable place cells in the hippocampus.\u003c\/p\u003e\n\n\u003cp\u003eActivity: The specific activity was determined to be 160 nmol\/min\/mg using Autocamtide-2 synthetic peptide (KKALRRQETVDAL-amide) as substrate.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-His 478\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 85 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as sterile solution of 50mM Tris, 100mM NaCl, 0.5mM PMSF, 0.5mM Reduced Glutathione, pH 8.0\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 80.3 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 80 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104286736563,"sku":"PKSH030403-50","price":1003.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_ae329410-b4fa-4e2b-995c-7c3a8f696156.png?v=1709293801","url":"https:\/\/afsbio.com\/products\/recombinant-human-camk2a-camka-protein-gst-tagactive-pksh030403","provider":"AFSBio Inc.","version":"1.0","type":"link"}