{"product_id":"recombinant-human-carbonic-anhydrase-8-ca8-protein-his-tagactive-pksh032165","title":"Recombinant Human Carbonic Anhydrase 8\/CA8 Protein (His Tag)(Active) - PKSH032165","description":"\u003cp\u003eRecombinant Human Carbonic Anhydrase 8\/CA8 Protein (His Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032165-10, PKSH032165-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Carbonic Anhydrase 8; CA8\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Carbonic Anhydrase-Related Protein; CARP; Carbonic Anhydrase VIII; CA-VIII; CA8; CALS; CAMRQ3; MGC120502; MGC99509\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eApplication: Enzyme\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P35219\u003c\/p\u003e\n\n\u003cp\u003eAccession: P35219\u003c\/p\u003e\n\n\u003cp\u003eBackground: Carbonic Anhydrase 8 (CA8) belongs to the alpha-carbonic anhydrase family. Alpha-carbonic anhydrase is a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Because CA8 has some sequence similarity with other known carbonic anhydrase genes, it was firstly called as CA-related protein. Nevertheless, CA8 does not have a carbonic anhydrase catalytic activity. Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3), which is a congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mild mental retardation.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Measured by its esterase activity The specific activity is 162. 5 pmol\/min\/ug.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ala2-Gln290\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 1mM DTT, pH 8.5 .\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 34.0 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 40 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43118135345331,"sku":"PKSH032165-10","price":309.4,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43118135378099,"sku":"PKSH032165-50","price":509.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_caff95ee-90f5-4d55-8133-e0153db446a5.png?v=1709636852","url":"https:\/\/afsbio.com\/products\/recombinant-human-carbonic-anhydrase-8-ca8-protein-his-tagactive-pksh032165","provider":"AFSBio Inc.","version":"1.0","type":"link"}