{"product_id":"recombinant-human-cathepsin-d-ctsd-protein-his-tagactive-pksh030822","title":"Recombinant Human Cathepsin D\/CTSD Protein (His Tag)(Active) - PKSH030822","description":"\u003cp\u003eRecombinant Human Cathepsin D\/CTSD Protein (His Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSH030822-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Cathepsin D; CTSD\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Cathepsin D; CTSD; CLN10; CPSD; HEL-S-130P\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Signal Transduction; Cell biology; Neuroscience; Cancer;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P07339\u003c\/p\u003e\n\n\u003cp\u003eAccession: P07339\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cathepsin D (CTSD); a well known lysosomal aspartyl protease and belongs to the peptidase C1 family; which is a normal and major component of lysosomes; and is found in almost all cells and tissues of mammals. Its mostly described function is intracellular catabolism in lysosomal compartments; other physiological effect include hormone and antigen processing. Cathepsin D has a specificity similar to but narrower than that of pepsin A. Cathepsin D plays an important role in the degradation of proteins; the generation of bioactive proteins; antigen processing; etc. Among different role in cell physiology; a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. In addition; CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin; a potent endogenous inhibitor of angiogenesis; suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Measured by its ability to bind biotinylated human CTSS-His in a functional ELISA.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Leu 412\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 97 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile 25mM MES, 150mM NaCl, pH 6.5\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 44 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 40-110 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43107258269875,"sku":"PKSH030822-50","price":1213.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_f7aac043-bb66-49ef-bb3e-75d736dd4c9c.png?v=1709382055","url":"https:\/\/afsbio.com\/products\/recombinant-human-cathepsin-d-ctsd-protein-his-tagactive-pksh030822","provider":"AFSBio Inc.","version":"1.0","type":"link"}