{"product_id":"recombinant-human-cathepsin-s-ctss-protein-his-tagactive-pksh033736","title":"Recombinant Human Cathepsin S\/CTSS Protein (His Tag)(Active) - PKSH033736","description":"\u003cp\u003eRecombinant Human Cathepsin S\/CTSS Protein (His Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033736-10, PKSH033736-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Cathepsin S; CTSS\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Cathepsin S; CTSS; CTSS; MGC3886\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Tags \u0026amp; Cell Markers; Cell biology; immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: Enzyme\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P25774\u003c\/p\u003e\n\n\u003cp\u003eAccession: P25774\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. This protein is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Moreover, cathepsin S is expressed in some epithelial cells. Compared with the abundant cathepsins B, LandH, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A beta from amyloidogenic fragments of beta APP in the endosomal\/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease(AD) and Down Syndrome (DS).\u003c\/p\u003e\n\n\u003cp\u003eActivity: Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 The specific activity is 9063. 642 pmol\/min\/µg.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Gln17-Ile331(pro)\u0026amp;Ser109-Ile331\u0026amp;Gln17-Ser109(Propeptide)\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 36.9\u0026amp;25\u0026amp;11.2 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 37-40\u0026amp;26-28\u0026amp;14-16 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43118159986867,"sku":"PKSH033736-10","price":368.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43118160019635,"sku":"PKSH033736-50","price":625.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_4d346879-0289-49fc-a55c-1cf3a35398ef.png?v=1709637302","url":"https:\/\/afsbio.com\/products\/recombinant-human-cathepsin-s-ctss-protein-his-tagactive-pksh033736","provider":"AFSBio Inc.","version":"1.0","type":"link"}