{"product_id":"recombinant-human-cathepsin-z-protein-his-tagactive-pksh031822","title":"Recombinant Human Cathepsin Z Protein (His Tag)(Active) - PKSH031822","description":"Recombinant Human Cathepsin Z Protein (His Tag)(Active)\n\nSize: 50μg\n\nCatalogue Number: PKSH031822-50\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: Cathepsin Z\n\nTarget Symptom: Cathepsin Z; Cathepsin P; Cathepsin X; CTSZ\n\nResearch Area: Tags \u0026amp; Cell Markers\n\nTarget Species: Human\n\nExpression Host: HEK293 Cells\n\nApplication: Enzyme\n\nFusion Tag: C-His\n\nUNIProt ID: Q9UBR2\n\nAccession: Q9UBR2\n\nBackground: Cathepsin Z (CTSZ); also known as Cathepsin X or CATX; belongs to the C1 family of lysosomal cysteine proteases. Its gene structure and activity properties show several unique features that distinguish it clearly from other human cysteine proteases. It has a very short pro-region that shows no similarity to those of other cathepsins and a three-residue insertion motif that forms a characteristic ‘ mini loop’ . Cathepsin Z exhibits mono- and di-peptidase activity at its C-terminus; and in contrast to cathepsin B; it does not act as an endopeptidase. It is restricted to the cells of theimmune system; predominantly monocytes; macrophages and dendritic cells. Cathepsin Z is widely expressed in human tissues; suggesting that this enzyme could be involved in the normal intracellular protein degradation taking place in all cell types. It is capable to cleave regulatory motifs at C-terminus affecting the function of targeted molecules. Cathepsin X may regulate also the maturation of dendritic cells; a process; which is crucial in the initiation of adaptive immunity. Furthermore; higher levels of Cathepsin Z are also found in tumour and immune cells of prostate and gastric carcinomas and inmacrophages of gastric mucosa; especially after infection by Helicobacter pylori. Cathepsin Z is also ubiquitously distributed in cancer cell lines and in primary tumors from different sources; suggesting that this enzyme may participate in tumor progression.\n\nActivity: Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK (Dnp)-OH, R\u0026amp;D Systems, Catalog # ES005. The specific activity is \u0026gt; 800 pmoles\/min\/μg.\n\nSequence: Met 1-Val 303\n\nPurity: \u0026gt; 97 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 33 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43107395338419,"sku":"PKSH031822-50","price":1213.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_6424b821-032a-4540-92e1-887a84e75708.png?v=1709383094","url":"https:\/\/afsbio.com\/products\/recombinant-human-cathepsin-z-protein-his-tagactive-pksh031822","provider":"AFSBio Inc.","version":"1.0","type":"link"}