{"product_id":"recombinant-human-ccl1-i-309-protein-rp01613","title":"Recombinant Human CCL1\/I-309 Protein - RP01613","description":"\u003cp\u003eRecombinant Human CCL1\/I-309 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20ug, 50ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01613-10, RP01613-20, RP01613-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human CCL1\/I-309 Protein is produced by Pichia expression system. The target protein is expressed with sequence (Lys24-Lys96) of human CCL1\/I-309 (Accession #NP_002972.1) fused with no additional amino acid.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CCL1, I-309, P500, SCYA1, SISe, TCA3\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P22362\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 6346\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: CCL1 or chemokine (C-C motif) ligand 1, also known as I-309 or TCA-3, is a member of the chemokine (C-C motif) ligand family. The C-C chemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. I-309\/CCL1\/TCA-3 interacts with the G protein-linked transmembrane chemokine receptors CCR8 and induces biochemical events that may result in the control of chemotaxis, proliferation, apoptosis and adhesion. It has been demonstrated that I-309\/CCL1\/TCA-3 displays chemotactic activity for monocytes and other cell types such as NK cells and dendritic cells, but not for neutrophils. Furthermore, as the only known physiological ligand for CCR8, I-309\/CCL1\/TCA-3 was identified as a potent inhibitor of HIV-1 envelope-mediated cell-cell fusion and virus infection. I-309\/CCL1\/TCA-3 induces significant levels of LTC4 from elicited eosinophils.\u003c\/p\u003e\n\n\u003cp\u003eSource: Pichia\u003c\/p\u003e\n\n\u003cp\u003eTag: No tag\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: KSMQVPFSRCCFSFAEQEIPLRAILCYRNTSSICSNEGLIFKLKRGKEACALDTVGWVQRHRKMLRHCPSKRK\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198365262003,"sku":"RP01613-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198365294771,"sku":"RP01613-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198365327539,"sku":"RP01613-50","price":280.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_e0fb3b47-e8bd-4521-a870-8ecda19a7fe3.png?v=1766961240","url":"https:\/\/afsbio.com\/products\/recombinant-human-ccl1-i-309-protein-rp01613","provider":"AFSBio Inc.","version":"1.0","type":"link"}