{"product_id":"recombinant-human-ccl13-mcp-4-protein-rp01614","title":"Recombinant Human CCL13\/MCP-4 Protein - RP01614","description":"\u003cp\u003eRecombinant Human CCL13\/MCP-4 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01614-10, RP01614-20, RP01614-50, RP01614-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human CCL13\/MCP-4 Protein is produced by Pichia expression system. The target protein is expressed with sequence (Gln24-Thr98) of human CCL13\/MCP-4 (Accession #NP_005399.1) fused with no additional amino acid.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CCL13, CKb10, MCP-4, NCC-1, NCC1, SCYA13, SCYL1\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q99616\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 6357\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Monocyte Chemoattractant Proteins 4 (MCP-4\/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13\/MCP-4, is a CC family chemokine that is chemoattractant for eosinophils, basophils, monocytes, macrophages, immature dendritic cells, and T cells, and its capable of inducing crucial immuno-modulatory responses through its effects on epithelial, muscular and endothelial cells. Similar to other CC chemokines, CCL13 binds to several chemokine receptors (CCR1, CCR2 and CCR3), allowing it to elicit different effects on its target cells. A number of studies have shown that CCL13 is involved in many chronic inflammatory diseases, in which it functions as a pivotal molecule involved in the selective recruitment of cell lineages to the inflamed tissues and their subsequent activation. MCP-4\/CCL13 is secreted from chondrocytes and activates the proliferation of rheumatoid synovial cells, thereby leading to joint destruction in RA.\u003c\/p\u003e\n\n\u003cp\u003eSource: Pichia\u003c\/p\u003e\n\n\u003cp\u003eTag: No tag\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: QPDALNVPSTCCFTFSSKKISLQRLKSYVITTSRCPQKAVIFRTKLGKEICADPKEKWVQNYMKHLGRKAHTLKT\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198241464499,"sku":"RP01614-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198241497267,"sku":"RP01614-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198241530035,"sku":"RP01614-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198241562803,"sku":"RP01614-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_19226bfe-2369-4965-9253-e6025920f494.png?v=1766959621","url":"https:\/\/afsbio.com\/products\/recombinant-human-ccl13-mcp-4-protein-rp01614","provider":"AFSBio Inc.","version":"1.0","type":"link"}