{"product_id":"recombinant-human-ccl2-mcp-1-protein-rp01411","title":"Recombinant Human CCL2\/MCP-1 Protein - RP01411","description":"\u003cp\u003eRecombinant Human CCL2\/MCP-1 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01411-10, RP01411-20, RP01411-50, RP01411-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human CCL2\/MCP-1 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Gln24-Thr99) of human CCL2\/MCP-1 (Accession #NP_002973.1) fused with no additional amino acid.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P13500\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 6347\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, belongs to a group of CC chemokines located in chromosome 17q11.2. MCP-1 protein interacts with chemokine C-C motif receptor 2 (CCR2) to activate and recruit monocytes, macrophages, CD4+ T cells and immature dendritic cells to the site of infection. The presence of MCP-1 protein in an adequate concentration is important for granuloma formation and M. tuberculosis clearance.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: 1.Measured by the ability to inhibit the proliferation of HUVEC(Human Umbilical Vein Endothelial Cells).The ED50 for this effect is 0.53-2.12 ng\/mL.|2.Measured by its ability to chemoattract THP-1 cells. The ED50 for this effect is typically 1.01-4.04 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: E. coli\u003c\/p\u003e\n\n\u003cp\u003eTag: No tag\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198333542579,"sku":"RP01411-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198333575347,"sku":"RP01411-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198333608115,"sku":"RP01411-50","price":350.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198333640883,"sku":"RP01411-100","price":560.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_c047efe9-548a-4274-bbe9-1d6e6a285fd9.png?v=1766960707","url":"https:\/\/afsbio.com\/products\/recombinant-human-ccl2-mcp-1-protein-rp01411","provider":"AFSBio Inc.","version":"1.0","type":"link"}