{"product_id":"recombinant-human-ccl2-mcp-1-protein-rp01660","title":"Recombinant Human CCL2\/MCP-1 Protein - RP01660","description":"\u003cp\u003eRecombinant Human CCL2\/MCP-1 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: RP01660-10, RP01660-20\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human CCL2\/MCP-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Thr99) of human CCL2\/MCP-1 (Accession #NP_002973.1) fused with and a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30; CCL2\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P13500\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 6347\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its ability to chemoattract THP-1 cells. The ED50 for this effect is typically 3.33-13.32 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198350647475,"sku":"RP01660-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198350680243,"sku":"RP01660-20","price":280.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_3ae3f78e-7fe2-4e58-865e-21ef47f49721.png?v=1766960922","url":"https:\/\/afsbio.com\/products\/recombinant-human-ccl2-mcp-1-protein-rp01660","provider":"AFSBio Inc.","version":"1.0","type":"link"}