{"product_id":"recombinant-human-ccl3l1-protein-rp01834","title":"Recombinant Human CCL3L1 Protein - RP01834","description":"\u003cp\u003eRecombinant Human CCL3L1 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01834-10, RP01834-20, RP01834-50, RP01834-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human CCL3L1 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala24-Ala93) of human CCL3L1 (Accession #NP_001001437.2) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: LD78; 464.2; MIP1AP; SCYA3L; G0S19-2; SCYA3L1; D17S1718; LD78BETA; LD78-beta(1-70)\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P16619\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 6349\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The two human MIP-1 alpha genes arise by duplication\/mutation. They code for MIP-1 alpha isoforms CCL3\/LD78 alpha and CCL3L1\/LD78 beta, which share 94% amino acid (aa) sequence homology. Whereas the human CCL3\/LD78 alpha is a single-copy gene, the human CCL3L1\/LD78 beta gene copy number varies within the population. Human CCL3L1\/LD78 beta cDNA encodes a 93 aa residue precursor with a 23 aa residue signal peptide that is cleaved to generate a 70 aa mature protein. Human CCL3L1\/LD78 beta binds and signals through chemokine receptors CCR1 and CCR5. When compared to CCL3\/LD78 alpha, CCL3L1\/LD78 beta has higher binding affinity to CCR5, which also functions as a coreceptor for HIV-1 entry. The copy number of CCL3L1 is one of several genetic determinants of HIV-1 susceptibility (4).\u003c\/p\u003e\n\n\u003cp\u003eSource: E. coli\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: APLAADTPTACCFSYTSRQIPQNFIADYFETSSQCSKPSVIFLTKRGRQVCADPSEEWVQKYVSDLELSA\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198265974963,"sku":"RP01834-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198266007731,"sku":"RP01834-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198266040499,"sku":"RP01834-50","price":350.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198266073267,"sku":"RP01834-100","price":560.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_baedd7d4-3e2d-463e-a6b3-11503d2365ad.png?v=1766959902","url":"https:\/\/afsbio.com\/products\/recombinant-human-ccl3l1-protein-rp01834","provider":"AFSBio Inc.","version":"1.0","type":"link"}