{"product_id":"recombinant-human-cd155-pvr-necl5-protein-his-tagactive-pksh033563","title":"Recombinant Human CD155\/PVR\/NECL5 Protein (His Tag)(Active) - PKSH033563","description":"\u003cp\u003eRecombinant Human CD155\/PVR\/NECL5 Protein (His Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033563-10, PKSH033563-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CD155; PVR; NECL5\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Poliovirus Receptor; Nectin-Like Protein 5; NECL-5; CD155; PVR; PVS\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Microbiology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P15151\u003c\/p\u003e\n\n\u003cp\u003eAccession: P15151\u003c\/p\u003e\n\n\u003cp\u003eBackground: Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV); an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains; a transmembrane segment; and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms (α; β; γ; and δ) with identical extracellular domains.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized Human TIGIT-Fc(Cat: PKSH033510) at 5μg\/ml(100 μl\/well) can bind Human PVR-His. The ED50 of Human PVR-His is 11.66 ug\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Trp21-Asn343(Ile340Met)\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 36.13 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 58 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43118156513459,"sku":"PKSH033563-10","price":385.0,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43118156546227,"sku":"PKSH033563-50","price":735.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_236efc51-cb7d-4117-b8d3-d146b39e47e0.png?v=1709637241","url":"https:\/\/afsbio.com\/products\/recombinant-human-cd155-pvr-necl5-protein-his-tagactive-pksh033563","provider":"AFSBio Inc.","version":"1.0","type":"link"}