{"product_id":"recombinant-human-cd20-ms4a1-protein-aa-213-297-his-tag-pksh031312","title":"Recombinant Human CD20\/MS4A1 Protein (aa 213-297, His Tag) - PKSH031312","description":"\u003cp\u003eRecombinant Human CD20\/MS4A1 Protein (aa 213-297, His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 20μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSH031312-20\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CD20, MS4A1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: B1, Bp35, CD20, CVID5, LEU-16, MS4A1, MS4A2, S7\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, immunology, Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: NP_068769.2\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron\/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 \/ MS4A1 is expressed on all stages of B cell development except the first and last. CD20 \/ MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. CD20 \/ MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 \/ MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins, the numbers of circulating B-cells is usually in the normal range, but can be low.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Glu213-Pro297\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 83 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 12.1 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 23 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43155034341555,"sku":"PKSH031312-20","price":856.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_c5621b7b-c6f1-465b-8ba5-29255c1e7d30.png?v=1710437098","url":"https:\/\/afsbio.com\/products\/recombinant-human-cd20-ms4a1-protein-aa-213-297-his-tag-pksh031312","provider":"AFSBio Inc.","version":"1.0","type":"link"}