{"product_id":"recombinant-human-cd20-ms4a1-protein-trxa-tag-pksh030304","title":"Recombinant Human CD20\/MS4A1 Protein (TrxA Tag) - PKSH030304","description":"\u003cp\u003eRecombinant Human CD20\/MS4A1 Protein (TrxA Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSH030304-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CD20; MS4A1\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: B1; Bp35; CD20; CVID5; LEU-16; MS4A1; MS4A2; S7\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Cancer; immunology; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-Trx\u003c\/p\u003e\n\n\u003cp\u003eAccession: NP_068769.2\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD20 (membrane-spanning 4-domains; subfamily A; member 1); also known as MS4A1; is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron\/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 \/ MS4A1 is expressed on all stages of B cell development except the first and last. CD20 \/ MS4A1 is present from pre-pre B cells through memory cells; but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. CD20 \/ MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 \/ MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency; hypogammaglobulinemia; recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range; but can be low.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ile 141-Ser 188\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 80 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile 50 mM Tris, 150 mM NaCl, 1 mM EDTA, pH 8.0 \u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 23.9 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43107343007923,"sku":"PKSH030304-100","price":1372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_3148112e-21ba-4fac-b1d8-4a3db64a10b7.png?v=1709382707","url":"https:\/\/afsbio.com\/products\/recombinant-human-cd20-ms4a1-protein-trxa-tag-pksh030304","provider":"AFSBio Inc.","version":"1.0","type":"link"}