{"product_id":"recombinant-human-cd47-iap-protein-fc-tagactive-pksh032703","title":"Recombinant Human CD47\/IAP Protein (Fc Tag)(Active) - PKSH032703","description":"\u003cp\u003eRecombinant Human CD47\/IAP Protein (Fc Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032703-10, PKSH032703-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CD47; IAP\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Leukocyte Surface Antigen CD47; Antigenic Surface Determinant Protein OA3; Integrin-Associated Protein; IAP; Protein MER6; CD47; MER6\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Cancer; immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-Fc\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q08722\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q08722\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD47(Integrin-Associated Protein; IAP) is a 40 - 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages; neutrophils; and T cells. CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin; and it may play a role in membrane transport and signal transduction. This protein has broad tissue distribution; and is reduced in expression on Rh erythrocytes.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized Human SIRPA-His(Cat: PKSH033525) at 0.8μg\/ml(100 μl\/well) can bind Human CD47-Fc. The ED50 of Human CD47-Fc is 0.135 ug\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Gln19-Pro139\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB; 150mM NaCl; pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 41.9 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 60 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43118148649139,"sku":"PKSH032703-10","price":249.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43118148681907,"sku":"PKSH032703-50","price":732.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_f1236a5e-bb23-4227-8d1d-8fc45e4af9ed.png?v=1709637098","url":"https:\/\/afsbio.com\/products\/recombinant-human-cd47-iap-protein-fc-tagactive-pksh032703","provider":"AFSBio Inc.","version":"1.0","type":"link"}