{"product_id":"recombinant-human-cd62l-l-selectin-protein-his-tag-pdeh100294","title":"Recombinant Human CD62L\/L-Selectin protein (His tag) - PDEH100294","description":"\u003cp\u003eRecombinant Human CD62L\/L-Selectin protein (His tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDEH100294-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CD62L; L-Selectin\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: L-selectin; Sell; CD62 antigen-like family member L; Leukocyte adhesion molecule 1 (LAM-1); Leukocyte-endothelial cell adhesion molecule 1; Lymph node homing receptor; Lymphocyte antigen 22 (Ly-22); Lymphocyte surface MEL-14 antigen; CD62L\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P30836\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Stem Cells; Cardiovascular; Immunology; signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P30836\u003c\/p\u003e\n\n\u003cp\u003eBackground: L-Selectin (also known as Leukocyte Selectin, LAM-1, LECAM-1, LECCAM-1, TQ1, Leu-8, MEL-14 antigen, DREG, lymph node homing receptor, CD62L), a member of the Selectin family, is a cell surface glycoprotein expressed constitutively on a wide variety of leukocytes. Two forms of L-Selectin have been reported, apparently arising as a result of post-translational modifications. The lymphocyte form shows an apparent molecular weight of 74 kDa, while the neutrophil form is 90 - 100 kDa. Human and mouse L-Selectin share 76% amino acid (aa) sequence homology. L-Selectin plays a role in the migration of lymphocytes into peripheral lymph nodes and sites of chronic inflammation, and of neutrophils into acute inflammatory sites. Acting in cooperation with P-Selectin and E-Selectin, L-Selectin mediates the initial interaction of circulating leukocytes with endothelial cells that produces a characteristic \"rolling\" of the leukocytes on the endothelium. This initial interaction, also involving ICAM-1 and VCAM-1, leads eventually to extravasation of the white blood cell through the blood vessel wall into the extracellular matrix tissue.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Trp 39-Asn 332\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 32.23 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 39 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43083542397107,"sku":"PDEH100294-100","price":165.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_54604abb-f8a0-477d-a591-4e73d279b91c.png?v=1708944385","url":"https:\/\/afsbio.com\/products\/recombinant-human-cd62l-l-selectin-protein-his-tag-pdeh100294","provider":"AFSBio Inc.","version":"1.0","type":"link"}